KLK5 and neoplasm: Comparing the bulk transcriptome profiles of the TD and nonTD patients (Figure 1E; Supplementary Figure S1E), the TD patients exhibited upregulation of keratins (KRT81, KRT6B, KRT15, KRT5) and kallikreins (KLK5, KLK6, KLK7), indicating active extracellular matrix (ECM) remodeling and tumor expansion (16–18).