Comparing the bulk transcriptome profiles of the TD and nonTD patients (Figure 1E; Supplementary Figure S1E), the TD patients exhibited upregulation of keratins (KRT81, KRT6B, KRT15, KRT5) and kallikreins (KLK5, KLK6, KLK7), indicating active extracellular matrix (ECM) remodeling and tumor expansion (16–18). This evidence concerns the gene KLK4 and neoplasm.