HLA-DRA and neoplasm: For instance, differentially expressed gene (DEG) analysis revealed that B cells and tumor cells in the nonTD cluster exhibit upregulation of marker genes in MHC-II pathway (e.g., HLA-DRB and HLA-DRA), whereas tumor cells in the TD cluster show upregulation of keratins (Figure 2D), supported by corresponding GO biology pathway (BP) term enrichments (Supplementary Figure S2D).