The findings from this study demonstrated that Cx43 expression was upregulated in mice with suppurative sepsis, whereas adiponectin downregulated Cx43 expression, providing evidence that adiponectin could attenuate LPS-induced apoptosis by suppressing Cx43 expression and protect against LPS-induced myocardial injury through activation of the PI3K/AKT signaling pathway. Here, ADIPOQ is linked to Sepsis.