In vitro and in vivo studies using single-arm versions of JNJ-61186372 targeting EGFR or c-MET showed the importance of its Fc activity—binding of the anti-EGFR arm and c-MET arm in inhibiting EGFR or c-MET-driven tumor cells is facilitated by Fc suggesting that the Fc function of JNJ-61186372 is essential for maximal tumor inhibition (96). This evidence concerns the gene EGFR and neoplasm.