Despite the limited scope of studies on c-MET signaling through single-cell analysis, both bulk and single-cell analyses converge to emphasize the overexpression of c-MET within a distinct subpopulation of glioma cells that exhibit traits such as strong hypoxia, inflammation, stem-like properties, metastatic potential, and neoplastic characteristics among ten subpopulations (46). Here, MET is linked to central nervous system cancer.