When taken together, the above observations (Figure 5A-F) that levels of nuclear p53 TF protein rise in an IL15-dependent manner (both prior to division and perhaps particularly within cycling cells) in ODN + IL15 stimulated CLL cultures and the earlier molecular finding that p53 TF directly transactivates miR15/miR16 in CLL cells [58] suggest that an IL15-driven p53 → miR15/miR16 pathway contributes to declining BCL2 protein as CLL cells undergo cycling. Here, TP53 is linked to B-cell chronic lymphocytic leukemia.