CD40 and B-cell chronic lymphocytic leukemia: Consistent with a known circulation of blood leukemic cells into lymphatic tissues [25], a relatively short-term (24–72 h) culture of circulating CLL cells with stimuli found in LNs, ligands for BCR or CD40, and cytokines elicits significantly elevated MCL1, BCLXL, and survivin (BIRC5) [26-29], with no evidenced change in BCL2 protein during this period [28,29].