Interestingly, while prior histological studies show an inverse relationship between Ki67 and BCL2 in some follicular lymphomas (FL), marginal zone lymphoma, and a subset of CLL/small lymphocytic lymphoma (SLL) [103], this inverse relationship did not apply to more aggressive mantle zone lymphoma, diffuse large B cell lymphoma (DLBCL) and certain other CLL/SLL [103]. The gene discussed is MKI67; the disease is B-cell chronic lymphocytic leukemia.