The top 20 KEGG pathways were “PI3K-Akt signaling pathway,” “Rap1 signaling pathway,” “Toxoplasmosis,” “Thyroid hormone signaling pathway,” “Small cell lung cancer,” “RNA degradation,” “Regulation of actin cytoskeleton,” “Proteoglycans in cancer,” “Phagosome,” “Pathogenic Escherichia coli infection,” “Leukocyte transendothelial migration,” “Leishmaniasis,” “Human papillomavirus infection,” “Hematopoietic cell lineage,” “Focal adhesion,” “ECM-receptor interaction,” “Cell adhesion molecules (CAMs),” “Bacterial invasion of epithelial cells,” “Axon guidance,” and “Amoebiasis” (Figure 2B). Here, AKT1 is linked to escherichia coli infection.