SASH1 and breast cancer: The SASH1 gene was first identified as a tumour suppressor gene whose downregulation exerted oncogenic effects in breast cancer (37), and studies have continued to confirm that reduced SASH1 expression is strongly correlated with cell growth, proliferation and metastasis in a variety of malignancies (e.g., gastric (38), colorectal (39), and skin (40) malignancies).