FOXO4 and colorectal cancer: Jian Bai et al (34) found that colorectal cancer cell-derived exosomal miR-128-3p could directly inhibit its downstream target gene FOXO4, leading to activation of the TGF-β/SMAD and JAK/STAT3 signalling pathways to promote epithelial-mesenchymal transition in colorectal cancer and exert oncogenic effects.