Tumors with BRAF V600E mutations had significantly lower TMB scores (4.6 mut/Mb) compared to other BRAF alterations and driver gene negative tumors (≥10.2 mut/Mb) yet had a significantly higher frequency of high PD-L1 scores (46%) than the other tumor groups (≤28%) (Figure 2D). This evidence concerns the gene CD274 and neoplasm.