CDKN2A and non-small cell lung carcinoma: Comparative sequencing studies have demonstrated distinct genomic profiles within NSCLC subtypes, with non-squamous NSCLC frequently harboring more alterations in oncogenes, including KRAS, EGFR, BRAF, and MET, while squamous cell carcinomas frequently have TP53 and CDKN2A mutations (5–8).