Comparative sequencing studies have demonstrated distinct genomic profiles within NSCLC subtypes, with non-squamous NSCLC frequently harboring more alterations in oncogenes, including KRAS, EGFR, BRAF, and MET, while squamous cell carcinomas frequently have TP53 and CDKN2A mutations (5–8). Here, TP53 is linked to squamous cell carcinoma.