KRAS, BRAF, STK11/KEAP1, MUTYH/RET, and RBM10/MET-associated modules showed the opposite trend, having significantly higher frequencies of adenocarcinoma cases as genomic alterations increased (P ≤ 0.02; Figures 4F–H; Supplementary Figures S2C, D). Here, MUTYH is linked to adenocarcinoma.