Comparing different KRAS alterations, tumors with KRAS G12D (6.2 mut/Mb), G12A (8.6 mut/Mb), G12V (8.6 mut/Mb), and Q61H (7 mut/Mb) alterations had the lowest TMB among tumors with KRAS alterations (<10 mut/Mb) and significantly lower TMB than all other tested KRAS tumor groups (≥10 mut/Mb) (Supplementary Figure S1A; Supplementary Table S4). This evidence concerns the gene KRAS and neoplasm.