Tumors with adenocarcinoma histology tended to have more cases with TMB of <10 mutations/Mb (P=1E-22) and negative PD-L1 (P=5E-8) compared to squamous cell carcinoma cases, however, showed a slight, but significant, enrichment of tumors with high/very high levels of these markers (P<0.02; Table 1). This evidence concerns the gene CD274 and squamous cell carcinoma.