Factors associated with short TTI included histological tumor Grade 3 (HR = 1.020, 95% CI = 1.002–1.038, p = 0.033), invasive subtype (HR+/HER2+: HR = 1.076, 95% CI = 1.056–1.096, p < 0.001; HR−/HER2+: HR = 1.062, 95% CI = 1.031– 1.095, p < 0.001; HR−/HER2−: HR = 1.060, 95% CI = 1.038–1.082, p < 0.001), higher cancer stage (Stage II: HR = 1.095, 95% CI = 1.076–1.114, p < 0.001; Stage III: HR = 1.234, 95% CI = 1.207–1.261, p < 0.001), and age >70 years (HR = 1.018, 95% CI = 1.002–1.035, p = 0.023). The gene discussed is ERBB2; the disease is neoplasm.