Notably, circUBE2G1 overexpression significantly increased the density of LYVE-1-positive microlymphatic vessels (MLD) in the intratumoral and peritumoral areas of footpad primary tumor tissues, confirming that circUBE2G1 promotes lymphangiogenesis in LUAD (Figures 4F, G). This evidence concerns the gene LYVE1 and neoplasm.