While previous research has noted PD-1 expression changes in T cells and antigen-presenting cells in bacterial sepsis (Zhong et al., 2023) or Candida bloodstream infections (Spec et al., 2016; Wurster et al., 2022), no studies have yet linked PD-1 expression alterations in colon tissues to the transition from C. albicans colonization to translocated infection. This evidence concerns the gene PDCD1 and infection.