It has been reported that with the inhibition of the SOD enzyme due to oxidants in ischemic tissue during myocardial ischemia/reperfusion, the amount of GSH decreases, the amount of MDA increases, and the cells turn into a form that is less resistant to the toxic side effects of oxygen radicals.7 In our study, decreased SOD enzyme activity and GSH levels were observed in rats with an ISO-induced MI model. Here, SOD1 is linked to myocardial ischemia.