When including all patients, the multivariable Cox Proportional hazards model adjusting for age, tumour size, lymph node status, HER2 status, ER status and grade estimated a hazard ratio of 1.84 (p-value = 0.008, 95% CI: 1.17;2.89) for patients in the high-risk group compared to those in the low-risk group (Fig. 8B). The gene discussed is ESR1; the disease is neoplasm.