However, our results also show that IFNAR1KD tumors grew much faster than parental controls, emphasizing the sometimes contradictory role of IFNAR signaling in cancer controlling immunosurveillance (Boukhaled et al, 2021) which might be exacerbated by αPD-L1 treatment and, as a consequence, may introduce potential challenges of intracellular IFN signaling inhibition strategies. This evidence concerns the gene IFNAR1 and cancer.