Considering that some of the effects of PTPN23 depletion on Notch receptors are reproduced in cancer cells, PTPN23 has been described as a tumor suppressor as is the case of ESCRT genes, and loss of PTPN23 contributes to mammary tumorigenesis by altering endocytic trafficking of cancer-relevant cargoes (Lin et al, 2011; Manteghi et al, 2016), it will be important in the future to understand whether Notch alteration contributes to tumorigenesis initiated by loss of PTPN23. The gene discussed is PTPN23; the disease is cancer.