Moreover, our studies show that selective blocking of the association of PDE4D9 from SERCA2a may distinctly restore the activities of SERCA2a while sparing the detrimental effects on other proteins, such as RyR2 in diabetic myocytes, which may present an effective strategy to improve the heart function of DCM patients. This evidence concerns the gene RYR2 and familial dilated cardiomyopathy.