At diagnosis, majority (92.5%) of the patients had only liver metastases, and 7.5% had concomitant hepatic and extrahepatic CRC metastases.(30,34-40,44-48,51-54,56,57) The mean plasma CEA level reported in 15 studies was 100.8ng/ml (1–8,456 ng/ml),(29-31,33,34,37-41,44,47,52,53,57) whereas the mean diameter of the resected liver metastases was 3.7cm (1–20 cm).(29-31,33-37,39-42,44,45,47,49,52,53,55-57). This evidence concerns the gene CEACAM5 and colorectal carcinoma.