Among the 629 individuals (60.2%) who had the Pi*ZZ genotype, most (51.5%) were male; the mean age was 55.6 ± 13.2 years; the mean age at diagnosis was 44.7 ± 16.7 years; the mean FEV1 was 66.9 ± 30.7%; the mean DLCO was 68.0 ± 23.2%; the mean COPD Assessment Test score was 13.2 ± 9.3 points; and 190 (30.2%) had received AAT replacement therapy. Here, SERPINA1 is linked to chronic obstructive pulmonary disease.