To control transfusion-transmitted disease, one of the strategies adopted in Brazil is the mandatory serological testing for human immunodeficiency virus (HIV) I/II, human T-lymphotropic virus (HTLV) I/II, hepatitis B (HB) (anti-HBc and HBsAg), hepatitis C (HC), syphilis, and Chagas disease. This evidence concerns the gene KRT88P and Hepatitis.