However, a previous study has shown that IL-10 was found mainly at the beginning of pulp inflammation when it was considered reversible.28 In this study, IL-10 was not significantly found in any period of analysis, which disagrees with another study, where there was an increase in IL-10 after contact of bioceramic materials with pulp cells.29 However, the difference in the experimental models used should be noted. The gene discussed is IL10; the disease is inflammatory response.