Among the interleukins, IL-6 is an important regulator of inflammation, and its levels are increased in pulp inflammatory processes.24 It is a multifunctional inflammatory cytokine synthesized in response to trauma or infection, which can activate specific cells that play an important role in the inflammatory reaction and bone resorption.26 A previous study found elevated IL-6 immunolabeling in early periods (24 to 72 hours)25, which did not occur in our study. The gene discussed is IL6; the disease is infection.