Notably, therapeutic application of HMP1G NPs also significantly increased the secretion of IL‐6, IL‐12, and TNF‐α, within the tumor, indicating activation of antitumor immunity (Figure 8H,J,K), and decreased the expression level of IL‐10 (Figure 8I), a factor known to promote the differentiation of naïve CD4+ T cells into Treg cells.[43, 44] This confirmed that HMP1G NPs promoted the high secretion of pro‐inflammatory cytokines and decreased the expression levels of anti‐inflammatory factors. This evidence concerns the gene CD4 and neoplasm.