Compared with WT littermates, FGF21 LKO mice developed more severe hepatic steatosis, injury, dyslipidemia, oxidative stress, and inflammation with ethanol feeding.[29] Hepatic FGF21 deficiency abolished the effects of ethyl lactate on improving ASH (Figure 7A–F; Figure S6, Supporting Information). The gene discussed is FGF21; the disease is fatty liver disease.