Previous findings from collagen‐induced arthritis mouse models revealed severe ankle joint stiffness due to abnormal Ca+2 signaling and IL‐6‐mediated NLRP3 inflammasome formation.[48] Similarly, patients in our study, as well as those previously reported with LMNA p.R527C MAD[11] exhibited ulcerated and stiff ankle joints, suggesting aberrant Ca+2 signaling as key factor in MAD. This evidence concerns the gene IL6 and arthritic joint disease.