Consistent with our hypothesis, B lymphocytes from patients with WSS showed reduced localization of all the major structural and functional centrosomal proteins such as AKAP9, NEDD1, γ-tubulin, GCP2, and Cep72, as demonstrated in the cancer cell line upon depletion of MLL; thus, our results are biomimetic. The gene discussed is KMT2A; the disease is cancer.