AKT1 and disease arising from reactivation of latent virus: HCMV-mediated downregulation of Akt signaling is critical for efficient lytic replication, while intact Akt signaling prevents virus replication in bone marrow-derived CD34+ HPCs [29,35,36] and hESC-derived CD34+ HPCs (S1A Fig), suggesting that Akt acts to limit virus replication in multiple cell types during lytic and latent infection.