Furthermore, infection of fibroblasts with the ΔmiR-UL36/112/148D virus resulted in reduced iP1- and iP2-driven transcript accumulation (Fig 6D and 6E), but no change in MIEP expression (Fig 6C), supporting a link between Akt levels and iP1 and iP2 transactivation. The gene discussed is AKT1; the disease is infection.