However, compared to WT HCMV infection, no significant difference was observed in phosphorylated levels of Akt substrates mTOR (Fig 5E and 5G), CREB (Fig 5F and 5H), or P70S6K (S5 Fig), likely as these components are direct or indirect targets of other viral gene products [31–33,43]. Here, CREB1 is linked to cytomegalovirus infection.