Intriguingly, during lytic infection miR-UL36, miR-UL112, and miR-UL148D only affect activation of a subset of the tested Akt effectors, including FOXO3a, PRAS40, and Akt itself, but not other effectors like CREB, mTOR, and P70S6K. The gene discussed is CREB1; the disease is infection.