Genetically proxied inhibition of ABCC8, equivalent to a 1-unit reduction in log odds of type 2 diabetes, was significantly associated with a lower risk of LS in GIGASTROKE but not in the MRI-confirmed cohort [GIGASTROKE: OR, 0.22 (95% CI, 0.10–0.49); MRI-confirmed: OR, 0.59 (95% CI, 0.15–2.25)]. The gene discussed is ABCC8; the disease is type 2 diabetes mellitus.