Genetically proxied blood pressure lowering through calcium channel blockers was associated with cSVD imaging markers, whereas genetically proxied high-density lipoprotein raising through cholesteryl ester transfer protein inhibitors, triglyceride lowering through lipoprotein lipase and weight lowering through gastric inhibitory polypeptide receptor were associated with lower risk of LS. The gene discussed is GIPR; the disease is Leigh syndrome.