The inverse variance-weighted drug MR analysis indicated that genetically proxied inhibition of CETP, equivalent to an increase of 1 mg/dl in HDL, was significantly associated with a lower risk of LS [GIGASTROKE: OR, 0.84 (95% CI, 0.76–0.93); MRI-confirmed: OR, 0.75 (95% CI, 0.62–0.91)], although the association with MRI-confirmed LS did not remain significant after FDR correction (Fig. 4). Here, CETP is linked to Leigh syndrome.