The RAAS role of APA is of particular interest, as RAA dysregulation has been proposed to play an important part in SARS-CoV-2 pathophysiology, with impaired ACE2 function being linked to some of the deleterious cardiovascular effects seen in COVID-19 such as increased pulmonary artery pressure and coagulation in swine models [36]. This evidence concerns the gene ACE2 and COVID-19.