While more study is required on the interplay of ACE2 and ENPEP in the intestine if APA is found to be a SARS-CoV-2 cofactor, the most interesting interactions between APA, ACE2, and SARS-CoV-2 are likely found in blood vessels, noting the overlapping expression profiles in pericytes [9, 73, 81] and the significance of the vascular system in COVID-19 [36, 82]. Here, ENPEP is linked to COVID-19.