R‐2HG is the product of a mutant IDH gene that exhibits tumor suppression and has an antitumor effect in leukemia and glioma via blockade of FTO‐mediated demethylation of and degradation of MYC/CEBPA transcripts.[33] Based on structure‐based virtual screening and testing in AML cell models, two other FTO inhibitors CS1 and CS2 were discovered. The gene discussed is FTO; the disease is acute myeloid leukemia.