METTL3 and lung adenocarcinoma: In HCC cells, m6A modification of the circular RNA SORE by methyltransferase complex (MTC) increases its stability and upregulation of circ‐RNA SORE which activates Wnt2b and β‐catenin thereby inducing sorafenib resistance.[104] METTL3 upregulation in Gefitinib and Osimertinib‐resistant lung adenocarcinoma (LUAD) mediates resistance by YAP/TAZ (Hippo) signaling pathway activation.