circMDK upregulation further activates the PI3K/Akt/mTOR pathway and promotes the proliferation, invasiveness, and migration of HCC cells.[38] In another study, METTL3‐mediated m6A modification on lncRNA NIFK‐AS1 is recognized by IGF2BP1 causing its stabilization which further activates Akt1. This evidence concerns the gene AKT1 and hepatocellular carcinoma.