ALKBH5 and leukemia: A high‐throughput virtual screening identified two compounds, 2‐[(1‐hydroxy‐2‐oxo‐2‐phenylethyl)sulfanyl]acetic acid and 4‐[(furan‐2‐yl)methyl]amino‐1,2‐diazinane‐3,6‐dione, as ALKBH5 inhibitors which have an antiproliferative effect against three leukemia cell lines (micromolar concentrations).[145] Through structure‐activity relationship analysis, another potent ALKBH5 inhibitor (20m) has been developed which contains a 1‐aryl‐1H‐pyrazole scaffold.[146] Structure‐based virtual screening gave rise to a “pyrazolo[1,5‐a]pyrimidine” derivative ALKBH5 inhibitor, DDO‐2728.