FOXO3 downregulation thus activates autophagic pathways and generates sorafenib resistance in HCC cells.[70] METTL16 downregulation is associated with cisplatin resistance in bladder cancer in which hypoxia‐inducible factor 2α (HIF‐2α) represses transcription of METTL16. The gene discussed is METTL16; the disease is urinary bladder cancer.