EMP3 and breast carcinoma: MGMT and APNG are the major DNA damage repair enzymes that repair lesions caused by temozolomide leading to resistance to this drug.[83] The m6A reader YTHDC1 plays a vital role in DNA damage repair and Adriamycin (doxorubicin) resistance in breast cancer cells, the expression of which is suppressed by epithelial membrane protein 3 (EMP3).