Exposure to hypoxic conditions enhances expression of ALKBH5 that demethylates the pluripotency factor NANOG mRNA at the 3′‐UTR region, thereby upregulating its expression and contributing to the BCSC development.[49] ALKBH5‐mediated overexpression of NANOG and FOXM1 leads to an increased stem cell population and cisplatin resistance in oral squamous cell carcinoma (OSCC). This evidence concerns the gene ALKBH5 and oral cavity squamous cell carcinoma.