METTL3 overexpression has been implicated in reduced differentiation of tumorigenic glioma cells and acute myeloid leukemia (AML) cells.[28] Enhanced METTL3 expression inhibits differentiation of hematopoietic stem/progenitor cells (HSPCs) whereas METTL3 depletion enhances differentiation and stalled progression of AML cells. This evidence concerns the gene METTL3 and central nervous system cancer.