EMP3 overexpression inhibits breast cancer cell proliferation, overcoming chemoresistance, and is associated with more favorable patient survival.[84] Likewise, doxorubicin resistance in triple‐negative breast cancer (TNBC) is due to low reactive oxygen species (ROS) and superoxide dismutase (SOD2) overexpression caused by FOXO1, a master regulator of cellular ROS. This evidence concerns the gene EMP3 and breast cancer.