In CRC cells, METTL3 enhances the m6A abundance on Sce62 mRNA which is read by IGF2BP1 thereby increasing its stability for regulation of stemness behavior of the cancer cells and multidrug resistance.[41] METTL3 overexpression has been implicated in reduced differentiation of tumorigenic glioma cells (also associated with the stem cell attributes of glioblastoma stem‐like cells (GSCs)). This evidence concerns the gene IGF2BP1 and cancer.