YTHDF2 destabilizes DDX58 mRNA, which encodes for RIG‐I; this results in reduced CD8+ T lymphocyte infiltration into the tumor tissues and the urothelium.[96] The m6A demethylase, ALKBH5, contributes to anti‐PD1 antibody therapy resistance in melanoma by enhancing the stability of its target transcript Mct4 which otherwise would be degraded by YTHDF2. This evidence concerns the gene CD8A and melanoma.