CD274 and cancer: Lysosomal proteolytic digestion is responsible for immune evasion of cancer cells by degradation of tumor‐specific antigens and MHC‐I resulting in resistance to anti‐PD‐L1 and anti‐CTLA‐4 monoclonal antibodies.[93] In CRC, YTHDF1 enhances translation of the m6A‐modified p65 which upregulates CXCL1.