YTHDF2 and neoplasm: These protumorigenic macrophages show increased expression of the m6A reader, YTHDF2, although it is not clear how YTHDF2 contributes to protumoral macrophage polarization and chemoresistance.[99] VIRMA‐mediated m6A modification also promotes the immune escape of metastatic breast cancer cells by promoting collagen alignment in the extracellular matrix (ECM) and reducing CD8+ T cell infiltration in the tumor microenvironment.