METTL3 and cancer: TFAP2C in turn activates the DNA repair genes WEE1 G2 checkpoint kinase (WEE1) and breast cancer type 1 (BRCA1) attenuating cisplatin‐induced DNA damage.[82] METTL3‐mediated m6A modification is an underlying cause of temozolomide resistance in glioblastoma due to DNA damage repair.