NANOG and oral cavity squamous cell carcinoma: Exposure to hypoxic conditions enhances expression of ALKBH5 that demethylates the pluripotency factor NANOG mRNA at the 3′‐UTR region, thereby upregulating its expression and contributing to the BCSC development.[49] ALKBH5‐mediated overexpression of NANOG and FOXM1 leads to an increased stem cell population and cisplatin resistance in oral squamous cell carcinoma (OSCC).