RIGI and neoplasm: YTHDF2 destabilizes DDX58 mRNA, which encodes for RIG‐I; this results in reduced CD8+ T lymphocyte infiltration into the tumor tissues and the urothelium.[96] The m6A demethylase, ALKBH5, contributes to anti‐PD1 antibody therapy resistance in melanoma by enhancing the stability of its target transcript Mct4 which otherwise would be degraded by YTHDF2.