METTL3 and colorectal carcinoma: Increased infiltration of M2‐type macrophages in CRC cells induces METTL3 expression which enhances m6A levels in the TRAF5 transcript (an inducer of necroptosis) causing its destabilization and downregulation and resulting in oxaliplatin‐induced necroptosis inhibition and resistance.[98] Protumorigenic polarization of the macrophage population was also observed in breast cancer samples from triple‐negative breast cancer (TNBC) patients receiving chemotherapy.