Heterozygous variants in TINF2 are primarily de novo, but families with AD inheritance have been reported.1,3 AD inheritance (AD–non-TINF2) is associated with a better overall survival (median overall survival, 64.9 years), while recessive (AR or XLR) and AD-TINF2 genotypes manifest with more severe clinical phenotypes, leading to significant lower median overall survival (median overall survival, 31.8 and 37.9 years, respectively) compared with AD–non-TINF2. This evidence concerns the gene TINF2 and Alzheimer disease.