To investigate the role of LYRM2 in HCC cells, we established cell lines with stable overexpression of LYRM2 in Hep3B (Figure S2A,B) and Huh7 (Figure S2C,D), as well as cell lines with LYRM2‐knockdown inMHCC97H (Figure S3A,B) and HCCLM3 (Figure S3C,D). Here, LYRM2 is linked to hepatocellular carcinoma.