While, IL‐17A neutralization by intracerebroventricular injection of anti‐IL‐17A antibody can remarkably inhibit microglia activation and decrease the abnormally increased expression levels of IL‐1β, IL‐6, and TNF‐α in the hippocampus and cortex of psoriasiform dermatitis mice, promote hippocampal neurogenesis, thus alleviate the depressive‐like behaviors. The gene discussed is IL6; the disease is Psoriasiform dermatitis.