IMQ treatment resulted in significant skin structural and histopathological characters of psoriasiform dermatitis with elevated serum IL‐17A levels, obvious depressive‐like behaviors, microglia activation with increased IL‐1β, IL‐6, and TNF‐α expression levels in the hippocampus and cortex, and notable inhibition of hippocampal neurogenesis. Here, TNF is linked to Psoriasiform dermatitis.