TGFBR2 and lung disorder: Interestingly, we observed a similar pattern of lung disease as 1D11 treatment when deleting Tgfbr2 in the lung mesenchyme: Tgfbr2F/F;Gli1-CreERT2 mice developed alveolar simplification in normoxia when compared to littermate controls, and they developed worse disease than their littermates with hyperoxia exposure (Figure 6—figure supplement 2A and B).