Seven key genes, namely, CEACAM1, CEACAM6, IL1RN, PLAUR, STAT1, TGFB1, and THBS2, offer clinicians potential biomarkers warranting further analysis for IPMN stratification and treatment targets for invasive PDAC. The gene discussed is IL1RN; the disease is pancreatic intraductal papillary-mucinous neoplasm.