Besides structure, ferritin also offers a wide range ofattractive characteristics like uniform nanosize, easy functionalization,and low cost for large-scale production.5,6 Therefore,we aimed to design ferritin–drug nanoconjugates as a singleand/or dual drug carrier that can effortlessly bind to tumor cellsvia the naturally occurring transferrin receptor 1 (TfR1) in cancercells, generated as an effect of disordered iron metabolism homeostasis,leading to its endocytosis for targeted delivery. The gene discussed is TFRC; the disease is neoplasm.