PPP2CA and systemic lupus erythematosus: Forced expression of miRNA-155 decreases relative expression of PP2Ac and increases IL-2 release in c PBMCs in vitro. Ex vivo expression of PP2AC mRNA correlates with SLEDAI scores. Patients with SLE exhibit increased activity of the PP2A catalytic subunit resulting in decreased IL-2 production in T cells [188].