A GWAS involving 636 SLE patients with steroid-associated osteonecrosis (95 588 controls, Japanese Biobank) identified previously not know risk loci, namely MIR4293/MIR1265 (OR = 1.99), TRIM49 (Tripartite Motif Containing 49)/NAALAD2 (N-acetylated alpha-linked acidic dipeptidase-2) (OR = 1.65) and MYO16 (Myosin-16) (OR = 3.91) [43]. The gene discussed is NAALAD2; the disease is systemic lupus erythematosus.