Subsequently, pure somatic deletions of LRP1B were also discovered in gastric cancer, breast cancer, glioma, esophageal squamous cell carcinoma, and oral squamous cell carcinoma [14, 15, 16, 17, 18], while promoter region methylation of LRP1B was found in thyroid cancer, gastric cancer, esophageal squamous cell carcinoma, and oral squamous cell carcinoma cell lines [13, 14, 17, 18]. Here, LRP1B is linked to central nervous system cancer.