Nonspecific (21) and CRF1R+ (22) CeA-LH CRF+ neurocircuitry have been mapped previously in rats and associated with avoidance of stress-associated stimuli and stress-induced anxiety-like behavior and ethanol self-administration, and we provide evidence of a CRF+ CeA→LH circuit in our CRH-ires-cre mice here. This evidence concerns the gene PLOD1 and Anxiety.