To ensure a comprehensive collection of patient cases, we leveraged open-source data from major cancer projects like TCGA and CPTAC to explore the interactive expression patterns of ETAA1 and RPA1 with PD-L1, as well as multiple correlations with the mediators of PD-L1 nuclear translocation and PD-L1 associated nuclear transcriptional factors. The gene discussed is CD274; the disease is cancer.