found that lactate excreted by tumor cells into the tissue interstitium could be taken up by endothelial cells with the help of MCT1, which inhibited the degradation of HIF-1α in nonhypoxic endothelial cells and significantly upregulated endothelial cell production of VEGF and fibroblast growth factor (FGF), thus promoting angiogenesis (61) (Figure 3). This evidence concerns the gene VEGFA and neoplasm.