For instance, while PSTPIP2 exhibits protective effects against acute liver injury (ALI) and fibrosis, it paradoxically facilitates viral replication in hepatitis C. A profound understanding of these mechanisms is paramount for the development of targeted therapeutic strategies that can harness the immunomodulatory potential of PSTPIP2 without exacerbating undesirable effects. Here, PSTPIP2 is linked to hepatitis C virus infection.