Studies on CRISPR Cas9-mediated EZH2 knockdown in breast cancer cell lines MDA-MB-231, MCF7, and BT549, reported DNA demethylation and consequent upregulation of miR-124-3p and inhibition of its target gene CCL2, which helps recruit macrophages to the tumor site (20). The gene discussed is CCL2; the disease is neoplasm.