- CMV/BK - recruitment of proinflammatory mediators, Natural Killer (NK), CD8 & γδ T-cells (27, 35, 36).- Bacterial infection – Pyelonephritis (renal allograft rejection), pseudomonas spp (lung transplant rejection) immune infiltration and alloimmunity (3, 29). This evidence concerns the gene CD8A and bacterial infectious disease.