Our investigation highlights CD36, S100A10, and CSNK1A1 as pivotal features in atherosclerosis, showcasing their collective prowess In terms of diagnosis, prognosis, and therapeutic performanceEmploying single-cell sequencing, we conducted a thorough bioinformatics analysis to integrate novel modular genes emerging in the atherosclerosis microenvironment via high-dimensional weighted gene co-expression network analysis, focusing on monocytes within the diseased microenvironment. Here, CD36 is linked to atherosclerosis.