Recently, we investigated the role of innate immunity in VSMCs and related aortic pathologies through transcriptome analyses of aortas from proatherogenic apolipoprotein E deficient (Ape−/−) mice during both angiotensin II-induced aortic abdominal aneurysm (AAA) and an Ape−/− atherosclerosis over time. The gene discussed is APOE; the disease is triple-A syndrome.