Targets were highly enriched in 213 pathways (Supplementary Table S1), such as those associated with fluid shear stress and atherosclerosis, lipid and atherosclerosis, chemical carcinogenesis receptor activation, cyclic nucleotides (cAMP) signaling pathway, mitogen-activated protein kinase (MAPK) signaling pathway, AGE-RAGE signaling pathway in diabetes complications and other disease pathways. Here, WNK2 is linked to diabetes mellitus.