TARDBP and early-onset autosomal dominant Alzheimer disease: Numerous studies have demonstrated the potential of αSyn to interact with pTau,48,49 Aβ50,51 and TDP-43.52-54 Furthermore, the amygdala-predominant variant of αSyn is more commonly observed in Alzheimer’s disease,13 raising important questions about its potential involvement in CA1 region degeneration.