TARDBP and Alzheimer disease: (iii) Finally, although we did not detect a direct effect of αSyn on CA1 neuronal density in Alzheimer’s disease samples, our model on the full cohort, including controls, indicated that the overall relationship between amygdala-predominant αSyn pathology and CA1 neuronal density was observable after controlling for hippocampal TDP-43 and Braak NFT stages.