Amygdala-predominant αSyn pathology is often associated with comorbid Alzheimer’s disease neuropathological changes (ADNC),7,13,14,16 which includes amyloid β (Aβ) plaques, neuritic plaques and neurofibrillary tangles (NFTs) consisting of abnormal phosphorylated tau protein (pTau). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.