TARDBP and early-onset autosomal dominant Alzheimer disease: To test this hypothesis, we evaluated the differences in neuropathological profiles of Alzheimer’s disease cases with these two patterns of αSyn pathology distribution and carried out multivariate statistical analyses to identify the association between αSyn variant, pTau, phosphorylated TDP-43 (pTDP-43) pathology and hippocampal neuron loss.