Similarly, when adjusted for age, education and Apoε4 status, males with hypothyroidism showed significantly lower scores on ACE memory [β (95% CI) = −0.723 (−1.329, −0.118), P = 0.019], reading and sentence comprehension [β (95% CI) = −0.294 (−0.567, −0.020), P = 0.035] and form matching [β (95% CI) = −0.435 (−0.844, −0.025), P = 0.038] tasks as compared with euthyroid males. This evidence concerns the gene APOE and hypothyroidism.