Pathological accumulation of the TDP-43 protein due to mutations in the TARDBP gene is another hallmark feature of ALS.TDP-43 not only participates in RNA processing and transport as an RNA-binding protein but its misfolding and aggregation trigger disruption of protein homeostasis in ALS patients (Kurashige et al., 2022). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.