An analysis of keywords and references highlights the importance of #2 (Gene Therapy), #4 (DNA Methylation), #6 (Protein Aggregation), and #13 (Viral Vectors) as a focus of research, which is shifting towards understanding the biological mechanisms of ALS.Cu/Zn The role of SOD1 and AMPA receptors in the pathogenesis of ALS has emerged as an important area of research. Here, SOD1 is linked to amyotrophic lateral sclerosis.