The most cited literature was Bruijn et al. (2004), a systematic review of the mechanisms of motor neuron degeneration in ALS, followed by Neumann et al. (2006) ubiquitinated TDP-43 in frontotemporal lobar degenerative diseases and amyotrophic lateral sclerosis, and then by Vance et al. (2009), a study that examined the effects of ubiquitination on motor neuron degeneration by localization analysis of mutant proteins in a British lineage with familial (ALS) type 6, identifying missense mutations in the gene encoding fusion sarcolemmal protein (FUS), revealing the underlying mechanism of ALS. The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.