SOX4 and cancer: SOX4 is a transcription factor, which, during normal development, plays many important roles in stemness, differentiation, and cell fate.46 However, it has also been described as an oncogene that has been shown to be upregulated in more than 20 different types of cancers.8 In our dataset, combined with that from Riemondy et al.,5SOX4 was strikingly the only gene that was identified as a significant differentially expressed marker between earlier and later clones that was common in all Group 3 and Group 4 patients (Figure 6A and B, Supplementary Figure 9).