Of note, NCAM-1 upregulation has been correlated with poor prognosis in other types of cancers, including gliomas.49 In SHH and Group 4 MBs, the interaction within the MK signaling pathway occurred between the MDK ligand and the NCL receptor, and in both MB subgroups the outgoing signaling derived from cells with less mature neuronal markers. This evidence concerns the gene MDK and central nervous system cancer.