(36) analyzed the ratio of CD4 T cells, CD68 macrophages, CD8 T cells/CD68 macrophages and CD45RO T cells/CD68 macrophages and the prognosis of esophageal cancer patients, and the results of multivariate analysis showed that esophageal cancer patients with low CD45RO/CD68 ratio had poor DFS and OS. This evidence concerns the gene CD4 and esophageal cancer.