(37) Inhibition of glutamine synthetase induced antiproliferative effects in sarcoma cell lines (rhabdomyosarcoma, fibrosarcoma, osteosarcoma) including the liposarcoma derived cell line (SW872) In particular, liposarcoma cells were highly sensitive to the cytotoxic effects of antitumor enzyme L-asparaginase increasing glutamine synthetase levels and reducing cell proliferation. The gene discussed is GLUL; the disease is sarcoma.