PKNOX1 and melanoma: For example, lncRNA SPRIGHTLY can regulate melanocyte function by promoting melanocyte proliferation and reducing melanocytogenesis via UCA1 (38); lnc-PKNOX1-1 can inhibit melanoma development by regulating IL-8, thereby significantly inhibiting the proliferation, migration, and invasion of melanoma cells (39), which suggested its potential as an early diagnostic and therapeutic target for melanoma; lncRNA ZEB1-AS1 plays its role by activating the expression of ZEB1 gene, thereby affecting the aggressiveness and phenotypic transformation of melanoma (40).