It has been reported that high levels of HOTAIR are associated with poor prognosis in patients with melanoma, and HOTAIR can promote the growth and metastasis of melanoma cells by competitively binding to miR-152-3p, leading to the functional release of c-MET mRNA as well as the activation of the downstream PI3k/Akt/mTOR signaling pathway (41). This evidence concerns the gene MET and melanoma.