Studies also found that among ncRNAs, SAMMSON, TYRP1, SPRY4-IT1, UCA1, MALAT-1, HOTAIR, SLNCR1, ANRIL, and BANCR were also upregulated to some extent in melanoma specimens (24); considering the important role of ncRNAs in resistance and metastasis of cancer as well as autoimmune diseases, we also highlighted their role as promising prognostic and therapeutic targets for skin diseases. The gene discussed is SPRY4; the disease is cancer.